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The best way to protect yourself in this situation is to avoid going into work under the influence of marijuana. Refrain from using prescription marijuana a few hours prior to going into work if you live in a state where an employer can penalize marijuana use. While this may be difficult, especially if you are dealing with constant pain or another debilitating condition, it may be necessary. It is important for employees to prove that using medical marijuana does not make them irresponsible and that the substance does not interfere with their performance on the job.